Gait asymmetry in children with Duchenne muscular dystrophy: evaluated through kinematic synergies and muscle synergies of lower limbs

作者全名："Xiong, Qiliang; Liu, Yuan; Mo, Jieyi; Chen, Yuxia; Zhang, Lianghong; Xia, Zhongyan; Yi, Chen; Jiang, Shaofeng; Xiao, Nong"

作者地址："[Xiong, Qiliang; Mo, Jieyi; Zhang, Lianghong; Xia, Zhongyan; Yi, Chen; Jiang, Shaofeng] Nanchang Hangkong Univ, Dept Biomed Engn, Nanchang, Jiangxi, Peoples R China; [Liu, Yuan; Chen, Yuxia; Xiao, Nong] Chongqing Med Univ, Childrens Hosp, Dept Rehabil, Chongqing, Peoples R China"

通信作者："Xiao, N (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Rehabil, Chongqing, Peoples R China."

来源：BIOMEDICAL ENGINEERING ONLINE

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001040951400002

JCR分区：Q3

影响因子：2.9

年份：2023

卷号：22

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Background: Gait is a complex, whole-body movement that requires the coordinated action of multiple joints and muscles of our musculoskeletal system. In the context of Duchenne muscular dystrophy (DMD), a disease characterized by progressive muscle weakness and joint contractures, previous studies have generally assumed symmetrical behavior of the lower limbs during gait. However, such a symmetric gait pattern of DMD was controversial. One aspect of this is criticized, because most of these studies have primarily focused on univariate variables, rather than on the coordination of multiple body segments and even less investigate gait symmetry under a motor synergy of view. Methods: We investigated the gait pattern of 20 patients with DMD, compared to 18 typical developing children (TD) through 3D Gait Analysis. Kinematic and muscle synergies were extracted with principal component analysis (PCA) and non-negative matrix factorization (NNMF), respectively. The synergies extracted from the left and right sides were compared with each other to obtain a symmetry value. In addition, bilateral spatiotemporal variables of gait, such as stride length, percentage of stance and swing phase, step length, and percentage of double support phase, were used for calculating the symmetry index (SI) to evaluate gait symmetry as well. Results: Compared with the TD group, the DMD group walked with decreased gait velocity (both p < 0.01), stride length (both p < 0.01), and step length (both p < 0.001). No significant difference was found between groups in SI of all spatiotemporal parameters extracted between the left and right lower limbs. In addition, the DMD group exhibited lower kinematic synergy symmetry values compared to the TD group (p < 0.001), while no such significant group difference was observed in symmetry values of muscle synergy. Conclusions: The findings of this study suggest that DMD influences, to some extent, the symmetry of synergistic movement of multiple segments of lower limbs, and thus kinematic synergy appears capable of discriminating gait asymmetry in children with DMD when conventional spatiotemporal parameters are unchanged."

基金机构："National Natural Science Foundation of China [32000979, 62261039]; Natural Science Foundation of Jiangxi Province [20202BAB216019]; Nanchang Hangkong University [EA202208059]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (32000979, 62261039), the Natural Science Foundation of Jiangxi Province (20202BAB216019), and the Ph.D. fellowship of Nanchang Hangkong University (EA202208059)."