Should ICSI be implemented on patients with poor-quality embryos in the previous IVF cycle?

作者全名："Wang, Jiang; Xiong, Shun; Gao, Yang; Xia, Fei; Wei, Biao; Zou, Jiayi; Huang, Guoning; Han, Wei"

作者地址："[Wang, Jiang; Xiong, Shun; Gao, Yang; Xia, Fei; Wei, Biao; Zou, Jiayi; Huang, Guoning; Han, Wei] Chongqing Med Univ, Women & Childrens Hosp, Ctr Reprod Med, Chongqing Key Lab Human Embryo Engn, Chongqing, Peoples R China; [Wang, Jiang; Xiong, Shun; Gao, Yang; Xia, Fei; Wei, Biao; Zou, Jiayi; Huang, Guoning; Han, Wei] Chongqing Hlth Ctr Women & Children, Chongqing Clin Res Ctr Reprod Med, Chongqing, Peoples R China"

通信作者："Han, W (通讯作者)，Chongqing Med Univ, Women & Childrens Hosp, Ctr Reprod Med, Chongqing Key Lab Human Embryo Engn, Chongqing, Peoples R China."

来源：HELIYON

ESI学科分类：　

WOS号：WOS:001048675800001

JCR分区：Q1

影响因子：3.4

年份：2023

卷号：9

期号：7

开始页：　

结束页：　

文献类型：Article

关键词：Poor-quality embryo; Utilization rate; Clinical outcome; IVF; ICSI

摘要："This study was to evaluate whether Intracytoplasmic sperm injection (ICSI) can improve the quality of embryo in patients with poor-quality embryos in the previous In-vitro fertilization (IVF) cycle, which was cancelled before transfer. This was a retrospective cohort study of 178 IVF and 158 ICSI cycles for patients with poor-quality embryos in the previous IVF cycle in the Center for Reproductive Medicine, Women and Children's Hospital of Chongqing Medical University from March 2016 to June 2022. The 2 PN rate, oocyte utilization rate , high-quality embryo rate and clinical pregnancy rate were compared between the two groups. Furthermore, the implantation rate, miscarriage rate and cycle cancelation rate were measured and compared. ICSI resulted in a comparable 2 PN rate, oocyte utilization rate and cycle cancelation rate with IVF. The highquality embryo rate of ICSI group was significantly higher than that of IVF group (5.56% vs. 2.60%, P < 0.05). Eventually, a total of 239 patients performed embryo transfer. ICSI resulted in a significantly higher clinical pregnancy rate (55.56% vs. 40.98%, P < 0.05) compared with IVF, however, there were no notable differences in miscarriage rate and implantation rate. The present study suggested that ICSI significantly improved the high-quality embryo rate and clinical pregnancy of the patients with poor-quality embryos in the previous IVF cycle. Prospective randomized controlled trials are needed to further verify."

基金机构：Women and Children's Hospital of Chongqing Medical University [2021YJQN07]; Chongqing Natural Science Foundation of China [CSTB2022NSCQ-MSX0253]

基金资助正文：& nbsp;This work was supported by: The Women and Children's Hospital of Chongqing Medical University (grant number: 2021YJQN07) and Chongqing Natural Science Foundation of China (grant number: CSTB2022NSCQ-MSX0253) .