Development from recurrent anti-<i>N</i>-methyl-<i>D</i>-aspartate receptor encephalitis with seizures as the first symptom to autoimmune-associated epilepsy: a case report

作者全名:"Qin, Ningxiang; Wang, Jing; Peng, Xi; Wang, Liang"

作者地址:"[Qin, Ningxiang; Wang, Jing; Wang, Liang] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Peng, Xi] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 2, Chongqing 400010, Peoples R China"

通信作者:"Wang, L (通讯作者),Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing 400016, Peoples R China.; Peng, X (通讯作者),Chongqing Med Univ, Dept Neurol, Affiliated Hosp 2, Chongqing 400010, Peoples R China."

来源:ACTA EPILEPTOLOGICA

ESI学科分类: 

WOS号:WOS:001124804500001

JCR分区:Q4

影响因子:1.2

年份:2023

卷号:5

期号:1

开始页: 

结束页: 

文献类型:Article

关键词:Anti-N-methyl-D-aspartate receptor encephalitis; Autoimmune-associated epilepsy; Seizure; Relapse; Case report

摘要:"Background Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a novel autoimmune encephalitis (AE) first identified in 2007. It provides a new direction for clinicians when encountering unexplained symptoms such as seizures, psychotic behavioral abnormalities, speech disorders, and involuntary movements. Most patients have a good prognosis after immunotherapy, but some may experience relapses.Case presentation We report a Chinese female patient diagnosed with anti-NMDAR encephalitis. Over the past 30 years, the patient had experienced eight episodes with seizures as the first symptom, which eventually progressed to autoimmune-associated epilepsy. In the last two episodes, both serum and cerebrospinal fluid of the patient were negative for AE-related antibodies, and brain magnetic resonance imaging (MRI) revealed abnormal hyperintensity in the bilateral hippocampi. The patient's symptoms were poorly controlled by immunotherapy but well controlled by anti-seizure medicines.Conclusions Patients with a long history of AE and multiple relapses that start with seizures may display alterations of brain structure. Physicians should pay attention to autoimmune-associated epilepsy."

基金机构:"Joint Medical Research Project of Chongqing Science & Technology and Health Commission [2020FYYX081]; High-Level Medical Reserved Personnel Training Project of Chongqing; Natural Science Foundation of Yuzhong Direct, Chongqing [20190129]"

基金资助正文:"This work was supported by the Joint Medical Research Project of Chongqing Science & Technology and Health Commission (2020FYYX081), High-Level Medical Reserved Personnel Training Project of Chongqing, and Natural Science Foundation of Yuzhong Direct, Chongqing (20190129)."