"Long noncoding RNA (lncRNA) H19: An essential developmental regulator with expanding roles in cancer, stem cell differentiation, and metabolic diseases"

作者全名："Liao, Junyi; Chen, Bowen; Zhu, Zhenglin; Du, Chengcheng; Gao, Shengqiang; Zhao, Guozhi; Zhao, Piao; Wang, Yonghui; Wang, Annie; Schwartz, Zander; Song, Lily; Hong, Jeffrey; Wagstaff, William; Haydon, Rex C.; Luu, Hue H.; Fan, Jiaming; Reid, Russell R.; He, Tong-Chuan; Shi, Lewis; Hu, Ning; Huang, Wei"

作者地址："[Liao, Junyi; Chen, Bowen; Zhu, Zhenglin; Du, Chengcheng; Gao, Shengqiang; Zhao, Guozhi; Zhao, Piao; Hu, Ning; Huang, Wei] Chongqing Med Univ, Dept Orthoped Surg, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Liao, Junyi; Chen, Bowen; Zhu, Zhenglin; Du, Chengcheng; Gao, Shengqiang; Zhao, Guozhi; Zhao, Piao; Hu, Ning; Huang, Wei] Chongqing Med Univ, Dept Urol, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Liao, Junyi; Chen, Bowen; Zhu, Zhenglin; Du, Chengcheng; Gao, Shengqiang; Zhao, Piao; Hu, Ning; Huang, Wei] Chongqing Med Univ, Orthoped Res Ctr, Chongqing 400016, Peoples R China; [Liao, Junyi; Zhao, Guozhi; Wang, Yonghui; Wang, Annie; Schwartz, Zander; Song, Lily; Hong, Jeffrey; Wagstaff, William; Haydon, Rex C.; Luu, Hue H.; Fan, Jiaming; Reid, Russell R.; He, Tong-Chuan; Shi, Lewis; Hu, Ning] Univ Chicago, Dept Orthopaed Surg & Rehabil Med, Mol Oncol Lab, Med Ctr, Chicago, IL 60637 USA; [Wang, Yonghui] Shanghai Jiao Tong Univ, Dept Clin Lab Med, Sch Med, Shanghai 200000, Peoples R China; [Schwartz, Zander] Vanderbilt Univ, Sch Biomed Engn, Nashville, TN 37235 USA; [Wagstaff, William] Univ Chicago, Med Scientist Training Program, Pritzker Sch Med, Chicago, IL 60637 USA; [Fan, Jiaming] Chongqing Med Univ, Sch Lab Med, Dept Clin Biochem, Minist Educ,Key Lab Diagnost Med, Chongqing 400016, Peoples R China; [Reid, Russell R.; He, Tong-Chuan] Univ Chicago, Dept Surg Sect Plast Surg, Lab Craniofacial Suture Biol & Dev, Med Ctr, Chicago, IL 60637 USA"

通信作者："Liao, JY; Hu, N; Huang, W (通讯作者)，Chongqing Med Univ, Dept Orthoped Surg, Affiliated Hosp 1, Chongqing 400016, Peoples R China."

来源：GENES & DISEASES

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001017410300001

JCR分区：Q1

影响因子：6.8

年份：2023

卷号：10

期号：4

开始页：1351

结束页：1366

文献类型：Review

关键词：Epigenetic; Metabolic diseases; Stem cell

摘要："Recent advances in deep sequencing technologies have revealed that, while less than 2% of the human genome is transcribed into mRNA for protein synthesis, over 80% of the genome is transcribed, leading to the production of large amounts of noncoding RNAs (ncRNAs). It has been shown that ncRNAs, especially long non-coding RNAs (lncRNAs), may play crucial regulatory roles in gene expression. As one of the first isolated and reported lncRNAs, H19 has gained much attention due to its essential roles in regulating many physiological and/ or pathological processes including embryogenesis, development, tumorigenesis, osteogenesis, and metabolism. Mechanistically, H19 mediates diverse regulatory functions by serving as competing endogenous RNAs (CeRNAs), Igf2/H19 imprinted tandem gene, modular scaffold, cooperating with H19 antisense, and acting directly with other mRNAs or lncRNAs. Here, we summarized the current understanding of H19 in embryogenesis and development, cancer development and progression, mesenchymal stem cell lineage-specific differentiation, and metabolic diseases. We discussed the potential regulatory mechanisms underlying H19's functions in those processes although more in-depth studies are warranted to delineate the exact molecular, cellular, epigenetic, and genomic regulatory mechanisms underlying the physiological and pathological roles of H19. Ultimately, these lines of investigation may lead to the development of novel therapeutics for human diseases by exploiting H19 functions. 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons."

基金机构："National Natural Science Foundation of China (NSFC) [82002312, 81972069]; National Institutes of Health, USA [CA226303, DE030480]; Science and Technology Research Program of Chongqing Education Commission, China [KJQN202100431, KJZD-M202100401]; Top Talent Award from The First Affiliated Hospital of Chongqing Medical University, China [BJRC2021-04]; Culti-vation Program of Postdoctoral Research of The First Affiliated Hospital of Chongqing Medical University, China [CYYY-BSHPYXM-202202]; Chongqing Medical University; China Postdoctoral Science Foundation [2022M720605]; Science and Technology Research PlanProject of Chongqing Education Commission, China [KJQN201900410, 298]; Natural Science Foundation of China [82102696]; Medical Scientist Training Program of the National Institutes of Health, USA [T32 GM007281]; University of Chicago Cancer Center Support Grant, USA [P30CA014599]; National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health, USA [5UL1TR002389]; Mabel Green Myers Research Endowment Fund; University of Chicago Orthopedics Alumni Fund"

基金资助正文："The reported work was supported by the National Natural Science Foundation of China (NSFC) (No. 82002312, 81972069) . The reported work was supported in part by research grants from the National Institutes of Health, USA (No. CA226303 to TCH and No. DE030480 to RRR) . This project was also supported by the Science and Technology Research Program of Chongqing Education Commission, China (No. KJQN202100431, KJZD-M202100401) , the Top Talent Award from The First Affiliated Hospital of Chongqing Medical University, China (No. BJRC2021-04) and Cultivation Program of Postdoctoral Research of The First Affiliated Hospital of Chongqing Medical University, China (No. CYYY-BSHPYXM-202202) . JY was supported by a post-doctoral fellowship from Chongqing Medical University and rewarded by China Postdoctoral Science Foundation (No. 2022M720605) . JF was supported in part by research grants from the 2019 Science and Technology Research PlanProject of Chongqing Education Commission, China (No. KJQN201900410) , the 2019 Funding for Postdoctoral Research (Chongqing Human Resources and Social Security Bureau No. 298) , and the Natural Science Foundation of China (No. 82102696) . WW was supported by the Medical Scientist Training Program of the National Institutes of Health, USA (No. T32 GM007281) . This project was also supported in part by The University of Chicago Cancer Center Support Grant, USA (No. P30CA014599) and the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health, USA (No. 5UL1TR002389) . TCH was supported by the Mabel Green Myers Research Endowment Fund and The University of Chicago Orthopedics Alumni Fund. Funding sources were not involved in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication."