Synergistic inhibition of NUDT21 by secretory S100A11 and exosomal miR-487a-5p promotes melanoma oligo- to poly-metastatic progression

作者全名："Zeng, Bin; Chen, Yuting; Chen, Hao; Zhao, Qiting; Sun, Zhiwei; Liu, Doudou; Li, Xiaoshuang; Zhang, Yuhan; Wang, Jianyu; Xing, H. Rosie"

作者地址："[Zeng, Bin; Zhao, Qiting; Sun, Zhiwei; Wang, Jianyu] Chongqing Med Univ, Inst Life Sci, Chongqing, Peoples R China; [Chen, Yuting; Chen, Hao; Liu, Doudou; Li, Xiaoshuang; Zhang, Yuhan; Xing, H. Rosie] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China; [Wang, Jianyu; Xing, H. Rosie] Yi Xue Yuan Rd, Chongqing 400016, Peoples R China"

通信作者："Wang, JY; Xing, HR (通讯作者)，Yi Xue Yuan Rd, Chongqing 400016, Peoples R China."

来源：MOLECULAR ONCOLOGY

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001019398300001

JCR分区：Q1

影响因子：6.6

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：exosome; glycolysis; miR-487a-5p; Nudt21; S100A11; Sec23a

摘要："Although early diagnosis and therapeutic advances have transformed the living quality and outcome of cancer patients, the poor prognosis for metastatic patients has not been significantly improved. Mechanisms underlying the complexity of metastasis cannot be simply determined by the straight-forward 'cause-and-effect relationships'. We have developed a 'dry-lab-driven knowledge discovery and wet-lab validation' approach to embrace the complexity of cancer and metastasis. We have revealed for the first time that polymetastatic (POL) melanoma cells can utilize both the secretory protein pathway (S100A11-Sec23a) and the exosomal crosstalk (miR-487a-5p) to transfer their 'polymetastatic competency' to the oligometastatic (OL) melanoma cells, via synergistic co-targeting of the tumor-suppressor Nudt21. The downstream deregulated glycolysis was verified to regulate metastatic colonization efficiency. Further, two gene sets conferring independent prognosis in melanoma were identified, which have the potential for clinical translation and merit future clinical validation."

基金机构："National Natural Science Fund [82073277, 82173247]; Science and Technology Project Affiliated to the Education Department of Chongqing [KJQN202100404]; Project of Chongqing Natural Science Foundation Innovation and Development Fund (Municipal Education Commission) [CSTB2022NS CQ-LZX0023]"

基金资助正文："Acknowledgements This work was supported by the National Natural Science Fund (Grant No. 82073277 and 82173247), the Science and Technology Project Affiliated to the Education Department of Chongqing (Grant No. KJQN202100404), and Project of Chongqing Natural Science Foundation Innovation and Development Fund (Municipal Education Commission; Grant No. CSTB2022NS CQ-LZX0023)."