Lipidomics reveal the cognitive improvement effects of Acer truncatum Bunge seed oil on hypoxic-ischemic encephalopathy rats

作者全名："Chen, Xianyang; Song, Wangting; Song, Yige; Cao, Hongli; Xu, Xiao; Li, Shujia; Fu, Yanmin; Xue, Teng; Ding, Chunguang; Lin, Feng; Shi, Yuan; Li, Jiujun"

作者地址："[Xu, Xiao; Li, Shujia; Fu, Yanmin; Li, Jiujun] China Med Univ, Plateau Med Res Ctr, Dept Pediat, Shengjing Hosp, Shenyang, Peoples R China; [Chen, Xianyang; Song, Wangting; Song, Yige; Xue, Teng] Bao Feng Key Lab Genet & Metab, Beijing, Peoples R China; [Cao, Hongli] Capital Med Univ, Dept Resp Rehabil, Beijing Rehabil, Beijing, Peoples R China; [Ding, Chunguang] Natl Ctr Occupat Safety & Hlth, Beijing, Peoples R China; [Lin, Feng] Fujian Med Univ, Dept Neurol, Sanming Hosp 1, Sanming, Fujian, Peoples R China; [Shi, Yuan] Chongqing Med Univ, Dept Neonatol, Childrens Hosp, Chongqing, Peoples R China"

通信作者："Li, JJ (通讯作者)，China Med Univ, Plateau Med Res Ctr, Dept Pediat, Shengjing Hosp, Shenyang, Peoples R China.; Chen, XY; Song, WT (通讯作者)，Bao Feng Key Lab Genet & Metab, Beijing, Peoples R China."

来源：FOOD & FUNCTION

ESI学科分类：AGRICULTURAL SCIENCES

WOS号：WOS:001020698100001

JCR分区：Q1

影响因子：6.1

年份：2023

卷号：14

期号：14

开始页：6610

结束页：6623

文献类型：Article

关键词：　

摘要："Hypoxic-ischemic encephalopathy (HIE) is one of the leading causes of acute neonatal death and chronic neurological damage, and severe HIE can have secondary sequelae such as cognitive impairment and cerebral palsy, for which effective interventions are lacking. In this study, we found that continuous 30-day intake of Acer truncatum Bunge seed oil (ASO) reduced brain damage and improved cognitive ability in HIE rats. Using lipidomic strategies, we observed that HIE rats had decreased unsaturated fatty acids and increased lysophospholipids in the brain. However, after 30 days of ASO treatment, phospholipids, plasmalogens, and unsaturated fatty acids increased, while lysophospholipids and oxidized glycerophospholipids decreased in both serum and the brain. Enrichment analysis showed that ASO intake mainly affected sphingolipid metabolism, fat digestion and absorption, glycerolipid metabolism and glycerophospholipid metabolic pathways in serum and the brain. Cluster, correlation, and confirmatory factor analyses showed that cognitive improvement after ASO administration was attributed to increased essential phospholipids and & omega;3/6/9 fatty acids, coupled with decreased oxidized glycerophospholipids in HIE rats. Our findings indicate that ASO has the potential to be developed as an effective food supplement for ischemic hypoxic newborns."

基金机构："Shengjing Hospital of China Medical University [112-3110119086]; Department of Pediatrics, Shengjing Hospital of China Medical University"

基金资助正文："This study was funded by Shengjing Hospital of China Medical University through award no. 112-3110119086. We are especially thankful for the instrumentation support from the Department of Pediatrics, Shengjing Hospital of China Medical University."