Molecular epidemiology of hepatitis C virus genotypes in different geographical regions of Chinese mainland and a phylogenetic analysis

作者全名："Tang, Qiao; Chen, Zhiwei; Li, Hu; Zhang, Li; Peng, Mingli; Zeng, Yi; Liu, Xiaoqing; Liu, Zubi; Hu, Peng"

作者地址："[Tang, Qiao; Chen, Zhiwei; Li, Hu; Zhang, Li; Peng, Mingli; Zeng, Yi; Liu, Xiaoqing; Hu, Peng] Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Key Lab Mol Biol Infect Dis,Chines, 74 Linjiang Rd, Chongqing 400000, Peoples R China; [Liu, Zubi] Key Lab Digital Technol Med Diagnost Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China; [Liu, Zubi] Zhejiang Univ, Sch Med, Hangzhou 310000, Peoples R China"

通信作者："Hu, P (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Key Lab Mol Biol Infect Dis,Chines, 74 Linjiang Rd, Chongqing 400000, Peoples R China.; Liu, ZB (通讯作者)，Key Lab Digital Technol Med Diagnost Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China.; Liu, ZB (通讯作者)，Zhejiang Univ, Sch Med, Hangzhou 310000, Peoples R China."

来源：INFECTIOUS DISEASES OF POVERTY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:001025845300001

JCR分区：Q1

影响因子：8.1

年份：2023

卷号：12

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Hepatitis C virus; Genotype; Distribution; Phylogenetic analysis; China

摘要："BackgroundHepatitis C virus (HCV) infection remains a major public health problem in Chinese mainland. Investigation of the distribution of genotypes contributed to the prevention, diagnosis and treatment of HCV infection. Therefore, we conducted a study on the distribution of HCV genotypes and phylogenetic analysis to provide an up-to-date understanding of the molecular epidemiology of genotypes in Chinese mainland.MethodsOur retrospective multicenter study enrolled 11,008 samples collected between August 2018 and July 2019 from 29 provinces/municipalities (Beijing, Hebei, Inner Mongolia, Shanxi, Tianjin, Gansu, Ningxia, Shaanxi, Xinjiang, Heilongjiang, Jilin Liaoning, Henan, Hubei Hunan, Anhui, Fujian, Jiangsu, Jiangxi, Shandong, Shanghai Zhejiang, Guangdong, Guangxi, Hainan, Chongqing, Guizhou, Sichuan and Yunnan). Phylogenetic analysis of each subtype was performed to infer the evolutionary relationship of sequences from diverse regions. Two independent samples t tests were used for the comparison of continuous variables, and chi-square tests were used for the comparison of categorical variables.ResultsFour genotypes (1, 2, 3 and 6) were found, including 14 subtypes. HCV genotype 1 was dominant, accounting for 49.2%, followed by genotypes 2, 3 and 6, accounting for 22.4%, 16.4%, and 11.9%, respectively. Additionally, the top five subtypes were 1b, 2a, 3b, 6a and 3a. Proportions of genotypes 1 and 2 decreased while genotypes 3 and 6 increased over past years (P < 0.001). Genotypes 3 and 6 were concentrated in the population aged 30 to 50 years, and male carriers had lower proportions of subtypes 1b and 2a than female carriers (P < 0.01). Genotypes 3 and 6 were more prevalent in southern parts of Chinese mainland. Nationwide spreads of subtypes 1b and 2a were associated with sequences from northern parts of Chinese mainland, while subtypes 3a, 3b and 6a were associated with sequences from southern parts of Chinese mainland.ConclusionsHCV subtypes 1b and 2a remained the most common subtypes in Chinese mainland, and their proportions decreased over the past years, while the proportions of genotypes 3 and 6 increased. Our investigation provided an accurate epidemiological picture of the circulating viral strains in Chinese mainland, contributing to the prevention, diagnosis and treatment of HCV infection.Trial registration: Not applicable."

基金机构："Chongqing Talents Project [cstc2021ycjh-bgzxm0150]; First batch of key Disciplines on Public Health in Chongqing, Health Commission of Chongqing, China"

基金资助正文："This work was supported in part by grants from the Chongqing Talents Project (cstc2021ycjh-bgzxm0150) and the First batch of key Disciplines on Public Health in Chongqing, Health Commission of Chongqing, China."