Evidence for a causal relationship between psoriasis and cutaneous melanoma: a bidirectional two-sample Mendelian randomized study

作者全名:"Zhao, Nana; Guo, Pengsen; Tang, Mei; Yang, Fan; Zhang, Tongtong; Mao, Rui"

作者地址:"[Zhao, Nana; Tang, Mei] Third Peoples Hosp Chengdu, Dept Operating Room, Chengdu, Peoples R China; [Guo, Pengsen; Zhang, Tongtong] Third Peoples Hosp Chengdu, Ctr Gastrointestinal & Minimally Invas Surg, Chengdu, Peoples R China; [Yang, Fan] Peking Univ, Peking Univ Third Hosp, Sch Med, Emergency Dept, Beijing, Peoples R China; [Zhang, Tongtong] Chongqing Med Univ, Southwest Jiaotong Univ, Peoples Hosp Chengdu 3, Affiliated Hosp,Chengdu Hospital 2,Med Res Ctr, Chengdu, Sichuan, Peoples R China; [Mao, Rui] Cent South Univ, Xiangya Hosp, Dept Dermatol, Changsha, Peoples R China"

通信作者:"Mao, R (通讯作者),Cent South Univ, Xiangya Hosp, Dept Dermatol, Changsha, Peoples R China."












关键词:bidirectional two-sample mendelian randomization; psoriasis; cutaneous melanoma; genome-wide association study; SNP

摘要:"Background and objectiveExisting cross-sectional and retrospective studies were unable to establish a causal relationship between psoriasis and cutaneous melanoma (CM). We sought to evaluate the causal role between psoriasis and CM. MethodsWe performed a bidirectional two-sample Mendelian randomization analysis using summary statistics from genome-wide association studies of psoriasis and CM among individuals of predominantly European ancestry. Mendelian randomization-Egger regression, inverse variance weighting, Mendelian Randomization Pleiotropy RESidual Sum and Outlier, weighted mode, and weighted median were used to examine the causal effect between psoriasis and CM. ResultsGenetically predicted psoriasis was a significant risk factor for CM (odds ratio, 1.69; 95% confidence interval, 1.15-2.48; P = 0.025). In contrast, no association was observed between genetically predicted CM and psoriasis. ConclusionOur findings corroborated the existence of genetically predicted psoriasis increases risk of CM. Enhanced early screening of cutaneous melanoma in patients with psoriasis may improve clinical burden. However, we did not find evidence for a causal link from CM to psoriasis, so further studies are required to elucidate the effect of CM activity on psoriasis."