A Web-Based Instrument for Infantile Atopic Dermatitis Identification (Electronic Version of the Modified Child Eczema Questionnaire): Development and Implementation

作者全名："Fang, Heping; Chen, Lin; Li, Juan; Ren, Luo; Yin, Yu; Chen, Danleng; Yin, Huaying; Liu, Enmei; Hu, Yan; Luo, Xiaoyan"

作者地址："[Fang, Heping; Li, Juan; Ren, Luo; Liu, Enmei] Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders,Key Lab, Chongqing Key Lab Pediat,Dept Resp Med,Minist Edu, Chongqing, Peoples R China; [Chen, Lin; Yin, Yu; Chen, Danleng; Yin, Huaying; Hu, Yan] Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders,Key Lab, Chongqing Key Lab Child Hlth & Nutr,Minist Educ,D, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China; [Luo, Xiaoyan] Chongqing Med Univ, Childrens Hosp,Key Lab Child Dev & Disorders, Natl Clin Res Ctr Child Hlth & Disorders,Minist E, Chongqing Key Lab Child Infect & Immun,Dept Derma, Chongqing, Peoples R China"

通信作者："Hu, Y (通讯作者)，Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders,Key Lab, Chongqing Key Lab Child Hlth & Nutr,Minist Educ,D, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China."

来源：JOURNAL OF MEDICAL INTERNET RESEARCH

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001159244900002

JCR分区：Q1

影响因子：7.4

年份：2023

卷号：25

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：atopic dermatitis; identification; infant; web-based questionnaire; public health

摘要："Background: Atopic dermatitis (AD) is a chronic inflammatory cutaneous disease that affects 30.48% of young children; thus, there is a need for epidemiological studies in community settings. Web-based questionnaires (WBQs) are more convenient, time-saving, and efficient than traditional surveys, but the reliability of identifying AD through WBQs and whether AD can be identified without the attendance of doctors, especially in community or similar settings, remains unknown. Objective: This study aimed to develop and validate a web-based instrument for infantile AD identification (electronic version of the modified Child Eczema Questionnaire [eCEQ]) and to clarify the possibility of conducting WBQs to identify infantile AD without the attendance of doctors in a community-representative population. Methods: This study was divided into 2 phases. Phase 1 investigated 205 children younger than 2 years to develop and validate the eCEQ by comparison with the diagnoses of dermatologists. Phase 2 recruited 1375 children younger than 2 years to implement the eCEQ and verify the obtained prevalence by comparison with the previously published prevalence. Results: In phase 1, a total of 195 questionnaires were analyzed from children with a median age of 8.8 (IQR 4.5-15.0) months. The identification values of the eCEQ according to the appropriate rules were acceptable (logic rule: sensitivity 89.2%, specificity 91.5%, positive predictive value 97.1%, and negative predictive value 72.9%; statistic rule: sensitivity 90.5%, specificity 89.4%, positive predictive value 96.4%, and negative predictive value 75%). In phase 2, a total of 837 questionnaires were analyzed from children with a median age of 8.4 (IQR 5.2-14.6) months. The prevalence of infantile AD obtained by the eCEQ (logic rule) was 31.9% (267/837), which was close to the published prevalence (30.48%). Based on the results of phase 2, only 20.2% (54/267) of the participants identified by the eCEQ had previously received a diagnosis from doctors. Additionally, among the participants who were not diagnosed by doctors but were identified by the eCEQ, only 6.1% (13/213) were actually aware of the possible presence of AD. Conclusions: Infantile AD can be identified without the attendance of doctors by using the eCEQ, which can be easily applied to community-based epidemiological studies and provide acceptable identification reliability. In addition, the eCEQ can also be applied to the field of public health to improve the health awareness of the general population."

基金机构："General Program of National Clinical Research Center for Child Health and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China [NCRCCHD-2019-GP-0X]"

基金资助正文："This study was supported by grants from the General Program of National Clinical Research Center for Child Health and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China (grant NCRCCHD-2019-GP-0X)."